Related Experiment Video
Updated: May 10, 2025
06:34
The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
Published on: April 28, 2022
4.5K
Bioconversion of Fe3O4 Nanoparticles by Probiotics
Călina Ciont1,2, Amalia Mesaros3, Ana Maria Cocean1
1Department of Food Science, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Pharmaceuticals (Basel, Switzerland)
|April 26, 2025
Summary
Probiotics enhance iron bioavailability by adhering to iron oxide nanoparticles (Fe3O4 NPs). This probiotic-mediated approach increases iron absorption and reduces gastrointestinal side effects associated with traditional iron supplements.
Area of Science:
- Biotechnology
- Nanotechnology
- Microbiology
Background:
- Iron deficiency anemia is a global health issue.
- Conventional iron supplements have low bioavailability and cause side effects.
- Novel strategies are needed to improve iron supplementation.
Purpose of the Study:
- To investigate the potential of probiotics to enhance iron bioavailability.
- To explore probiotic-mediated mechanisms for improving iron absorption.
- To assess the interaction between probiotics and iron oxide nanoparticles (Fe3O4 NPs).
Main Methods:
- Synthesized Fe3O4 NPs using co-precipitation.
- Characterized NPs using electron microscopy and spectroscopy.
- Investigated interactions of Lactobacillus fermentum, L. rhamnosus, and L. plantarum with Fe3O4 NPs.
Main Results:
- Probiotics adhered to and were internalized by Fe3O4 NPs, with L. fermentum showing highest capacity.
- Probiotic metabolism facilitated Fe3O4 oxidation to Fe2O3.
- Fe3O4 NP treatment enhanced bacterial viability and metabolic activity, indicating synergy.
Conclusions:
- Probiotic-assisted iron supplementation shows promise for improving iron bioavailability.
- This approach may mitigate gastrointestinal side effects of iron supplements.
- Probiotics offer a novel strategy for enhanced iron delivery.
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