Acute Supplementation of Soluble Mango Leaf Extract (Zynamite^® S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Yolanda Castellote-Caballero ¹, Ana Beltrán-Arranz ², Agustín Aibar-Almazán ³

⁰Department of Health Sciences, Faculty of Health Sciences, University of Atlántico Medio, 35017 Las Palmas de Gran Canaria, Spain.

Pharmaceuticals (basel, Switzerland) +

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April 26, 2025

View abstract on PubMed

Summary

A soluble mango leaf extract, Zynamite® S, improved cognitive functions like processing speed and reduced mental fatigue in young adults. This natural nootropic enhanced emotional balance with sustained effects for at least five hours.

Area Of Science

Neuroscience
Pharmacology
Nutritional Science

Background

Mango leaf extract (Zynamite®), rich in mangiferin, is known to enhance brain activity and cognitive function.
Improving the solubility of Zynamite® may increase its efficacy as an active ingredient.
Zynamite® S (Zyn-S) is a soluble formulation designed to enhance the bioavailability of mangiferin.

Purpose Of The Study

To investigate the effects of Zynamite® S on cognitive function and mood in young adults.
To evaluate the efficacy of low doses of Zynamite® S.
To determine the duration of action for Zynamite® S.

Main Methods

A double-blind, placebo-controlled crossover study involving 119 university students.
Participants received 100 mg or 150 mg of Zynamite® S or placebo.
Cognitive tests (RAVLT, TMT, DSST, Stroop) and mood assessments (POMS) were administered pre- and post-intake at various time points.

Main Results

Zynamite® S significantly reduced tension, depression, and confusion, indicating improved mental clarity and emotional well-being.
Improvements were observed in processing speed and cognitive flexibility.
No significant changes were noted in short- and long-term verbal memory.

Conclusions

Zynamite® S acts as a natural nootropic, acutely enhancing cognitive functions and emotional balance in young adults.
Low doses of Zynamite® S demonstrate sustained efficacy for at least five hours.
The soluble formulation shows promise for improving cognitive performance and mood.

Keywords:

Mangifera indica Zynamite cognitive function mood university students