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Preparation and Characterization of Fenofibrate-Loaded Fibers Based on 2-Hydroxylpropyl-β-Cyclodextrin
Enikő Bitay1,2, Zoltán-István Szabó3,4, Attila Levente Gergely1
1Department of Mechanical Engineering, Faculty of Technical and Human Sciences, Sapientia Hungarian University of Transylvania, Calea Sighișoarei nr. 2, 540485 Târgu-Mureş, Romania.
Polymers
|April 26, 2025
Summary
This study enhanced fenofibrate dissolution by creating cyclodextrin fibers, achieving a 60-fold increase. This novel approach improves the delivery of fenofibrate (a class II drug) for cardiovascular health.
Area of Science:
- Pharmaceutical Science
- Drug Delivery Systems
- Materials Science
Background:
- Fenofibrate, a class II drug, exhibits poor solubility, limiting its therapeutic efficacy for dyslipidemia and associated cardiovascular risks.
- Improving fenofibrate's dissolution is crucial for enhancing its bioavailability and clinical outcomes.
Purpose of the Study:
- To develop novel 2-hydroxylpropyl-β-cyclodextrin (HPβCD) fibers for the first time to enhance fenofibrate's dissolution characteristics.
- To optimize the drug loading and electrospinning parameters for fenofibrate-loaded HPβCD fibers.
Main Methods:
- Single-needle electrospinning was employed to fabricate fenofibrate-loaded HPβCD fibers.
- Dimethylformamide was identified as a suitable solvent for fiber preparation.
- Characterization involved ultraviolet spectroscopy for drug loading, and differential scanning calorimetry and Fourier transform infrared spectroscopy for analyzing the drug's physical state within the fibers.
Main Results:
- Bead-free fenofibrate-loaded HPβCD fibers with an average diameter of 2.65 ± 0.82 μm were successfully prepared.
- Drug loading efficiency was determined to be 97.2%, closely matching the theoretical value.
- A significant 60-fold increase in fenofibrate dissolution rate was observed from the prepared fibers compared to micronized fenofibrate.
Conclusions:
- Electrospun HPβCD fibers represent a promising strategy for enhancing the dissolution of poorly soluble drugs like fenofibrate.
- This formulation approach can significantly improve fenofibrate's bioavailability, potentially leading to better management of dyslipidemia and reduced cardiovascular disease risk.
