Distribution and Prevalence of Ticks and Tick-Borne Pathogens at the Wildlife-Livestock Interface in Africa: A...

Ticks and tick-borne diseases (TBDs) significantly impact African animal health and agricultural productivity, especially at the wildlife-livestock interface. This systematic review analyzed 20 eligible studies from East, Southern, and limited parts of Central Africa to determine the distribution and prevalence of key tick species and associated pathogens. Rhipicephalus appendiculatus and Amblyomma variegatum were the most commonly reported tick species, with R. appendiculatus exhibiting up to 50.5% prevalence in cattle and buffalo in Uganda. The most frequently detected pathogens included Theileria parva, Anaplasma marginale, and Coxiella burnetii, with T. parva showing high prevalence in cattle populations coexisting with wildlife. Notably, geographic disparities were observed, with Central and West Africa being underrepresented. Most pathogen detections occurred in Kenya, Uganda, Tanzania, Botswana, and South Africa, indicating regional hotspots for tick-borne disease transmission. This review highlights the urgent need for enhanced surveillance, region-specific vector control programs, and integrated One Health approaches to address the ecological, agricultural, and zoonotic challenges of tick-borne pathogens across Africa.