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Updated: May 12, 2026

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Subtype AD Recombinant HIV-1 Transmitted/Founder Viruses Are Less Sensitive to Type I Interferons than Subtype D

Denis Omara1,2, Fortunate Natwijuka1,2, Anne Kapaata2

  • 1Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala P.O. Box 7062, Uganda.

Viruses
|April 26, 2025
PubMed
Summary

Transmitted/founder HIV-1 (TF) variants show differential resistance to type 1 interferons (IFN-I). Recombinant AD subtypes are more resistant than subtype D, suggesting IFN-I as a potential therapeutic strategy against TF viruses.

Keywords:
HIV-1resistancesensitivitytransmitter founder virusestype one interferons

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