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Integrating Complex Permittivity Measurements with Histological Analysis for Advanced Tissue Characterization.

Sandra Lopez-Prades1,2,3, Mónica Torrecilla-Vall-Llossera4, Mercedes Rus1

  • 1Pathology Department, Hospital Clinic Barcelona, C/Villarroel 170, 08036 Barcelona, Spain.

Sensors (Basel, Switzerland)
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Summary

This study links complex permittivity measurements to tissue histology. These findings enable better tissue characterization in pathology using electrical properties.

Keywords:
biological tissuescomplex permittivityhistologyopen-ended coaxial probe

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Area of Science:

  • Biomedical Engineering
  • Pathology
  • Electrical Engineering

Background:

  • Complex permittivity measurements offer a non-invasive method for tissue analysis.
  • Histological features are crucial for accurate tissue characterization.
  • Integrating these two methods can enhance diagnostic capabilities.

Purpose of the Study:

  • To establish a reliable method correlating complex permittivity measurements with specific histological features.
  • To investigate the association between electrical properties and tissue composition.
  • To explore the potential of in situ complex permittivity for pathology workflows.

Main Methods:

  • Measured complex permittivity of 148 fresh human tissue samples across 14 types (200 MHz–20 GHz) using an open-ended coaxial probe.
  • Collected tissue via punch biopsy, ensuring measurement area matched histological sampling.
  • Processed samples into formalin-fixed, paraffin-embedded (FFPE) blocks for histological analysis.

Main Results:

  • Complex permittivity values strongly correlated with histological features like fat content, necrosis, and fibrosis.
  • Most tissue samples with distinct histological features were differentiable based on their permittivity values.
  • The method accounted for statistical variability and instrumental uncertainties.

Conclusions:

  • Complex permittivity is a valuable tool for fresh tissue characterization in pathology.
  • This research provides a foundation for databases linking permittivity to histology for precise correlations.
  • In situ complex permittivity measurements can potentially improve pathology workflows and diagnostics.