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Updated: May 10, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Developing digital health technologies for frontotemporal degeneration.

Naomi Nevler^1,2, Debra Niehoff³, Amanda M Gleixner³

¹Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|April 26, 2025

Summary

This summary is machine-generated.

Digital health technologies (DHTs) are emerging tools to track frontotemporal degeneration (FTD) progression. Developing these technologies presents challenges but offers a path toward new FTD therapies.

Keywords:

dementia diagnostics digital health technologies disease progression and monitoring frontotemporal degeneration neurodegeneration

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Area of Science:

Neuroscience
Digital Health
Clinical Trials

Background:

Frontotemporal degeneration (FTD) is a rare neurodegenerative disease causing cognitive, behavioral, motor, and speech impairments.
No approved therapies exist to slow or stop FTD progression.
Disease heterogeneity and monitoring challenges hinder clinical trial progress.

Purpose of the Study:

To present digital health technologies (DHTs) for measuring FTD onset and progression.
To discuss challenges in developing DHTs for FTD.
To propose a roadmap for creating effective DHTs to aid FTD therapy development.

Main Methods:

Review of emerging DHTs designed to capture subtle clinical impairments in FTD.
Analysis of challenges encountered by DHT developers.
Formulation of a strategic roadmap for DHT development.

Main Results:

Numerous DHT tools are under development to assess FTD-related functional domain changes.
Significant challenges exist in creating robust and reliable DHTs for FTD.
A proposed roadmap offers guidance for developing fit-for-purpose DHTs.

Conclusions:

DHTs show promise for monitoring FTD and accelerating therapeutic development.
Addressing development challenges is crucial for realizing the potential of DHTs in FTD.
Successful DHT implementation can significantly benefit FTD patient care and drug discovery.