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A Chitosan-Containing Dual-Crosslinked Resilient Patch for Tissue Adhesive and Sealant.

Jiayu Yang1, Qiaoling Li1, Jianpeng Zhang1

  • 1College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P. R. China.

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|April 26, 2025
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Summary

This study introduces a novel chitosan-based bioadhesive patch (ANC) that effectively adheres to wet tissues, improving surgical safety. The ANC patch offers customizable mechanical properties and superior sealing performance for leakage, outperforming traditional fibrin glue.

Keywords:
adhesivechitosandual‐crosslinkedpatch

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Innovation

Background:

  • Adhesive patches are crucial for biomedical applications like tissue adhesion and sealing surgical leaks.
  • Current limitations include poor adhesion to wet tissues and lack of mechanical customization, increasing surgical risks.
  • Chitosan-based materials offer potential but require optimized formulations for enhanced performance.

Purpose of the Study:

  • To develop a novel chitosan-containing bioadhesive patch (ANC) with enhanced adhesion to wet tissues and tunable mechanical properties.
  • To evaluate the adhesion strength, sealing performance, and mechanical adaptability of the developed ANC patch.
  • To compare the efficacy of the ANC patch against commercially available fibrin glue for sealing stomach fluid leakage.

Main Methods:

  • Fabrication of a dual-crosslinked bioadhesive patch using carboxymethyl chitosan methacrylate (CMCS-MA), acrylic acid, and N-hydroxysuccinimide ester.
  • Characterization of the patch's adhesion to wet tissue surfaces, focusing on moisture removal and bonding mechanisms (hydrogen bonding, NHS-amine interaction).
  • Assessment of mechanical properties and swelling behavior, with performance comparison against fibrin glue using stomach fluid leakage model.

Main Results:

  • The ANC patch demonstrated rapid moisture removal from tissue surfaces, enabling robust adhesion.
  • Tunable mechanical performance and swelling behavior were achieved by adjusting CMCS-MA content.
  • ANC patches exhibited superior adhesion and sealing performance compared to fibrin glue in simulated stomach fluid leakage tests.

Conclusions:

  • The developed dual-crosslinked ANC patch effectively addresses the limitations of current tissue adhesives for wet environments.
  • This bioadhesive patch offers a promising alternative for tissue adhesion and leakage sealing in surgical procedures.
  • The design broadens the application scope of chitosan-based materials in advanced biomedical engineering.