PANoptosis: a potential target of atherosclerotic cardiovascular disease

Area of Science:

• Immunology
• Cell Biology
• Cardiovascular Science

Background:

• PANoptosis is a newly identified cell death pathway involving the innate immune system and PANoptosome assembly.
• It uniquely combines features of apoptosis, pyroptosis, and necroptosis, making single-pathway inhibition ineffective.
• Current research on PANoptosis primarily focuses on infectious diseases and cancer, with limited exploration in cardiovascular contexts.

Purpose of the Study:

• To review the assembly and molecular mechanisms of PANoptosis.
• To elucidate the role of PANoptosis in the pathogenesis of Atherosclerotic Cardiovascular Diseases (ASCVD).
• To provide novel perspectives for ASCVD prevention and treatment by targeting PANoptosis.

Main Methods:

• Literature review focusing on PANoptosis mechanisms and its link to cardiovascular diseases.
• Analysis of existing research on PANoptosome assembly and downstream effectors.
• Exploration of PANoptosis's role in myocardial infarction, ischemic cardiomyopathy, and ischemic stroke.

Main Results:

• PANoptosis is initiated by innate immunity, leading to PANoptosome formation and effector activation.
• Effective inhibition of PANoptosis can be achieved by targeting the PANoptosome complex.
• PANoptosis is implicated in the development of ASCVD, including myocardial infarction, ischemic cardiomyopathy, and ischemic stroke.

Conclusions:

• Targeting the PANoptosome presents a promising therapeutic strategy for inhibiting PANoptosis.
• Understanding PANoptosis's role in ASCVD is crucial for developing new treatments.
• This review highlights the potential of targeting PANoptosis for cardiovascular disease prevention and management.