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Lignin as a Bioactive Additive in Chlorzoxazone-Loaded Pharmaceutical Tablets.

Andreea Creteanu1, Gabriela Lisa2, Cornelia Vasile3

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania.

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|April 26, 2025
PubMed
Summary
This summary is machine-generated.

Lignin, a bioactive additive, was used to create drug-loaded tablets with improved antioxidant and antimicrobial properties. This study demonstrates lignin

Keywords:
antimicrobial propertiesantioxidantchlorzoxazoneligninmatrix tablets

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Hydrophilic matrices are crucial for controlled drug release.
  • Lignin's bioactive properties are being explored for pharmaceutical applications.

Purpose of the Study:

  • To investigate lignin as a bioactive additive in drug-loaded tablets.
  • To evaluate lignin's impact on chlorzoxazone release from hydrophilic matrices.
  • To assess the antioxidant and antimicrobial activities of lignin-containing tablets.

Main Methods:

  • Preparation of 500 mg tablets using Kollidon® SR (KOL) and chitosan (CHT) as matrix formers.
  • Incorporation of lignin (LIG) into tablet formulations (FLa, FLb, FLc).
  • Evaluation using FTIR, XRD, TG, DSC, and in vitro dissolution tests.

Main Results:

  • Lignin influenced the release characteristics of chlorzoxazone (CLZ).
  • A two-step release mechanism was observed: a burst effect followed by prolonged release.
  • Lignin-containing tablets exhibited enhanced antioxidant and antimicrobial activities, dose-dependently.
  • Antioxidant activity increased by 21.36% in formulation FLc.
  • Antimicrobial activity was enhanced against tested pathogens with increasing lignin concentration.

Conclusions:

  • Lignin can be utilized as a multifunctional pharmaceutical bioactive additive.
  • Lignin incorporation improves tablet antioxidant and antimicrobial properties.
  • Lignin's properties support its use in various pharmaceutical applications, potentially reducing drug dosage.