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Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
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Müller-Weiss Disease.

Sixu Lang1, Brandon Maggen2

  • 1*CarePoint Health, Mississauga, ON, Canada.

Journal of the American Podiatric Medical Association
|April 26, 2025
PubMed
Summary

This case report highlights successful conservative treatment for Müller-Weiss disease (osteonecrosis of the navicular bone). A multimodal approach significantly reduced midfoot pain, improving daily activities.

Area of Science:

  • Orthopedics
  • Podiatry
  • Radiology

Background:

  • Müller-Weiss disease is a rare condition causing osteonecrosis of the lateral navicular bone.
  • It typically presents with dorsal midfoot pain, significantly impacting daily activities.
  • Surgical intervention is the predominant treatment discussed in existing literature.

Purpose of the Study:

  • To report a case of successful conservative management for bilateral Müller-Weiss disease.
  • To evaluate the efficacy of a multimodal conservative treatment plan.
  • To present findings in a patient with multiple comorbidities.

Main Methods:

  • Conservative treatment included pain medication, custom ethylene vinyl acetate orthotics, and motion control shoes.
  • Physiotherapy focused on strengthening intrinsic foot muscles.

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  • Weight management strategies were also implemented.

    • Main Results:

    • The patient experienced a significant reduction in bilateral midfoot pain, decreasing from a 9/10 to 2/10 severity.
    • Improvements were noted after 10 months of consistent conservative treatment.
    • The patient's daily activities were less limited by pain.

    Conclusions:

    • Conservative treatment can be effective for bilateral Müller-Weiss disease, even in patients with comorbidities.
    • A multimodal approach combining medication, orthotics, footwear, physiotherapy, and weight management offers a viable alternative to surgery.
    • This case report is the first to document successful conservative management of bilateral Müller-Weiss disease with this comprehensive strategy.