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Updated: May 20, 2025

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Tumor-educated platelet, a potential liquid biopsy biosource in pancreatic cancer: A review.

Majid Zaki-Dizaji1, Zahra Taheri2, Mohammad Heiat3

  • 1Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|April 26, 2025
PubMed
Summary

Early detection of pancreatic cancer (PC) is crucial. Tumor-educated platelets (TEPs) in liquid biopsies show promise as a non-invasive biomarker for improved PC screening and diagnosis.

Keywords:
BiomarkerDiagnosisLiquid biopsyPancreatic cancerTumor-educated platelets

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Molecular Diagnostics

Background:

  • Pancreatic cancer (PC) is aggressive with poor prognosis, often diagnosed late due to asymptomatic development.
  • Late diagnosis significantly limits treatment effectiveness and patient outcomes.
  • Novel biomarkers are essential for improving early detection and screening of PC.

Purpose of the Study:

  • To explore the potential of platelets as a liquid biopsy source for pancreatic cancer.
  • To review the role of tumor-educated platelets (TEPs) in PC detection and monitoring.
  • To highlight the need for integrating platelet-based biomarkers into clinical practice.

Main Methods:

  • Review of current literature on liquid biopsy and platelet function in cancer.
  • Analysis of platelet alterations (number, size, activation, molecular content) in PC.
  • Investigation of TEPs as potential biomarkers for PC screening and management.

Main Results:

  • Platelets are significantly altered by cancer, offering a source for liquid biopsy.
  • TEPs capture tumor-derived molecules, reflecting cancer's molecular landscape.
  • Platelet-based liquid biopsies show potential for early PC detection, prognosis, and monitoring.

Conclusions:

  • Platelets represent a promising, non-invasive source for pancreatic cancer liquid biopsies.
  • TEPs offer a novel avenue for PC screening, early diagnosis, and personalized treatment strategies.
  • Further research and clinical integration of platelet biomarkers are warranted for improved PC patient care.