Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Segmental aneuploidy in human embryos is frequently mosaic with evidence of meiotic origin: insights from trophectoderm and inner cell mass analyses.

Fertility and sterility·2026

Same author

The 'Fertility Freefall': a complex phenomenon requiring a multifaceted approach.

Reproductive biomedicine online·2026

Same author

Salivary uric acid remote serial self-testing for prediction of adverse pregnancy outcomes of uteroplacental dysfunction.

Acta obstetricia et gynecologica Scandinavica·2026

Same author

Embryo warming using an ultrafast protocol: perinatal outcomes from 1020 births from a single UK IVF centre.

Reproductive biomedicine online·2026

Same author

Fertility preservation and family-building in transgender and non-binary patients: 14 years at a UK centre.

Reproductive biomedicine online·2026

Same author

Preimplantation genetic testing for aneuploidy 'rescues' poor-quality blastocysts and increases embryo availability for transfer: a 9-year single centre analysis.

Reproductive biomedicine online·2025

Same journal

Ovarian reserve markers in World Health Organization type 1 anovulatory disorders: a systematic review and meta-analysis.

Reproductive biomedicine online·2026

Same journal

Effect of embryo culture medium pH on live birth rate after IVF/ICSI: a double-blind, multicentre, randomized trial.

Reproductive biomedicine online·2026

Same journal

Response to: Clarifying Molecular Specificity and Outcome Definitions in Progestogen Route Meta-Analysis.

Reproductive biomedicine online·2026

Same journal

Polyendocrine metabolic ovarian syndrome and cardiometabolic profile in offspring: a propensity score matched cohort study.

Reproductive biomedicine online·2026

Same journal

Antinuclear antibodies in women with recurrent early pregnancy loss: prevalence and impact on subsequent pregnancy outcome.

Reproductive biomedicine online·2026

Same journal

Effect of adenomyosis on the cumulative live birth rate in oocyte donation cycles: a retrospective analysis.

Reproductive biomedicine online·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2025

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Published on: October 25, 2024

Resolving recurrent implantation failure.

¹London Women's Clinic, London, UK.

Reproductive Biomedicine Online

|April 26, 2025

Summary

This summary is machine-generated.

Recurrent implantation failure (RIF) may not be a rare condition. Successful embryo transfer depends on both embryo and endometrial quality, which can compensate for each other.

Keywords:

Biosensor Embryo Endometrium Euploid Recurrent implantation failure

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Fertility Sparing Procedure using Carbon Dioxide Fiber Laser Vaporization of Ovarian Endometrioma

Fertility Sparing Procedure using Carbon Dioxide Fiber Laser Vaporization of Ovarian Endometrioma

Published on: July 6, 2022

Related Experiment Videos

Last Updated: May 16, 2025

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Published on: October 25, 2024

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Fertility Sparing Procedure using Carbon Dioxide Fiber Laser Vaporization of Ovarian Endometrioma

Fertility Sparing Procedure using Carbon Dioxide Fiber Laser Vaporization of Ovarian Endometrioma

Published on: July 6, 2022

Area of Science:

Reproductive medicine
Embryology
Gynecology

Background:

Recurrent implantation failure (RIF) presents a significant clinical challenge with evolving definitions and limited evidence for optimal management.
Recent studies suggest cumulative success rates challenge the concept of RIF as solely a rare biological event, questioning the endometrium's primary role.

Purpose of the Study:

To explore the interplay between embryo and endometrial factors in determining successful implantation.
To propose a new paradigm for understanding and investigating recurrent implantation failure.

Main Methods:

Literature review and synthesis of current research on implantation failure.
Analysis of studies investigating endometrial receptivity and embryo quality.

Main Results:

The endometrium functions as a biosensor, with its integrity existing on a spectrum rather than a binary receptive/non-receptive state.
Successful implantation is determined by the combined quality of both the embryo and the endometrium, with potential for partial compensation between the two.

Conclusions:

A new paradigm integrating both embryo- and endometrium-centric views is proposed for RIF.
This integrated approach may offer a more fruitful direction for future research and clinical investigation into recurrent implantation failure.