Emerging targets for advancing endometrial therapeutics

The endometrium plays a crucial role in female health. Globally, millions of women are affected by endometrial/uterine disorders, yet the endometrium and its role in gynaecological pathologies have been understudied. Gaining insight into the detailed endometrial architecture, gene expression, spatial and temporal cellular interactions, and microenvironment is essential for understanding the physiology and pathophysiology of this dynamic tissue. The current paper highlights the latest targets for advancing endometrial research that include single-cell RNA sequencing, spatial transcriptomics, the microbiome, organoid models, analysis of menstrual blood and the less-studied endometrial ageing. The authors hope that this summary will provide more insight into the novel methods, highlight advancing endometrial therapeutics and inspire readers to generate fresh ideas for future research avenues.