[Clinical analysis of 10 cases of pregnancy complicated with Behçet's disease]

Objective: To investigate the clinical characteristics of pregnancy complicated with Behçet's disease, so as to improve the diagnosis and treatment of the disease and improve maternal and neonatal outcomes. Methods: A retrospective analysis was conducted on the clinical data of 10 pregnant women with Behçet's disease, who were admitted to Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from January 2016 to June 2024. The maternal and neonatal outcomes were analyzed. Results: The 10 pregnant women with Behçet's disease had a mean age of (31.2±5.3) years (range: 25-41 years). Nine were diagnosed before pregnancy and one was diagnosed during the second trimester of pregnancy. The mean age of disease onset was (20.5±6.1) years (range: 10-34 years). Clinical manifestations included oral ulcers, genital ulcers, fever, uveitis, hematochezia, diarrhea, constipation, and skin rash. Nine of them received medication during pregnancy, while one did not. The disease conditions of five women were active during pregnancy and other five remained stable. In terms of delivery mode, five women had vaginal delivery and five delivered by cesarean section. Nine delivered at term and one had preterm delivery. All neonates survived without adverse outcomes. Conclusions: The management of pregnancy complicated with Behçet's disease requires a multidisciplinary team approcach. Individualized decisions regarding medication, timing of delivery, and mode of delivery are essential to achieve optimal maternal and fetal outcomes.