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Venous thromboembolism in patients undergoing pancreatic cancer surgery (PaTR-VTE) with curative intent; protocol of a prospective observational study

  • 0Department of Anaesthesiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa University Hospital, Thessaly, Greece. maria.ntalouka@icloud.com.
Bmc Surgery +

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April 26, 2025

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April 26, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study investigates the neutrophil/lymphocyte ratio (NLR) and coagulation biomarkers as predictors of venous thromboembolism (VTE) in pancreatic cancer surgery patients. Findings may optimize perioperative care for this high-risk group.

Area Of Science

  • Oncology
  • Hematology
  • Surgical Research

Background

  • Pancreatic cancer is strongly associated with venous thromboembolism (VTE), occurring in up to 18% of patients.
  • The precise mechanisms driving VTE in pancreatic cancer remain poorly understood.
  • This study focuses on patients undergoing surgery with curative intent for resectable pancreatic cancer.

Purpose Of The Study

  • To evaluate the neutrophil/lymphocyte ratio (NLR) and other coagulation biomarkers as predictors of VTE.
  • To determine the incidence of VTE in patients undergoing pancreatic cancer surgery.
  • To identify potential determinants of VTE in this patient population.

Main Methods

  • Prospective, observational study (STROBE compliant) of patients with resectable pancreatic cancer undergoing surgery.
  • Exclusion criteria include prior VTE, high ASA score, inoperable status, or concurrent malignancies.
  • Blood samples analyzed preoperatively, postoperatively, and before discharge for various hematologic and coagulation parameters; VTE screening via ultrasound one month post-procedure.

Main Results

  • The study aims to identify predictors of VTE, with a specific focus on the neutrophil/lymphocyte ratio (NLR).
  • Secondary objectives include assessing VTE incidence and perioperative coagulation status.
  • Sample size estimated at 62 patients for specificity outcome of NLR in VTE prediction.

Conclusions

  • The study seeks to identify predictors of postoperative VTE in pancreatic cancer surgery.
  • Results are expected to inform and optimize perioperative care strategies.
  • Improved understanding of VTE predictors may reduce complications in high-risk surgical patients.

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