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Updated: May 10, 2025

Minimally Invasive Muscle Embedding MIME - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
Published on: August 24, 2017
Progress on the regulation of muscle regeneration by microRNA
Tai-Zeng Zhou1,2,3, Qiu-Yang Chen1,2,3, Yi-Ting Yang1,2,3
1National Key Laboratory of Pig and Poultry Seed Industry, Sichuan Agricultural University, Chengdu 611130, China.
Abstract:
MicroRNA (miRNA) is a class of single-stranded non-coding short RNA molecules about the size of 22 nt. Currently, miRNA has received the most extensive research and attention, and miRNA has been shown to be involved in the post-transcriptional regulation of gene expression in almost all cellular events, including cell proliferation, migration, differentiation, and apoptosis. miRNA plays an important role in the process of muscle regeneration by targeting key factors at different stages of skeletal muscle regeneration. In this review, we summarize the role of miRNA in regulating muscle regeneration by affecting satellite cell quiescence, myoblast proliferation, and differentiation during muscle regeneration, and update the relationship between miRNA and PI3K/AKT, TGF-β/Smad signaling during muscle regeneration. The research progress of pathway interaction will help researchers to learn more about the knowledge of miRNA in muscle regeneration biology, and provide a better understanding of the involvement of non-coding RNAs in muscle regeneration.
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