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Updated: May 10, 2025

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 27, 2010
An overview of host immune responses against Leishmania spp. infections
Hanna Paton1,2,3, Prabuddha Sarkar1,2, Prajwal Gurung1,2,3,4,5,6
1Inflammation Program, University of Iowa, 431 Newton Road, Iowa City, IA 52242, United States.
Abstract:
Leishmania spp. infections pose a significant global health challenge, affecting approximately 1 billion people across more than 88 endemic countries. This unicellular, obligate intracellular parasite causes a spectrum of diseases, ranging from localized cutaneous lesions to systemic visceral infections. Despite advancements in modern medicine and increased understanding of the parasite's etiology and associated diseases, treatment options remain limited to pentavalent antimonials, liposomal amphotericin B, and miltefosine. A deeper understanding of the interactions between immune and non-immune cells involved in the clearance of Leishmania spp. infections could uncover novel therapeutic strategies for this debilitating disease. This review highlights recent progress in elucidating how various cell types contribute to the regulation and resolution of Leishmania spp. infections.
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