A noninvasive optical method to measure oxygen tension at the corneal epithelium

Corneal redox fluorometry is presented as an alternative method to noninvasively measure the oxygen tension in equilibrium with the tear film. The application of this method to the study of the effects of a contact lens on the tear film oxygen tension is described. The development of a clinical corneal redox fluorometer would permit noninvasive measurements of the effects of contact lens induced corneal hypoxia on corneal physiology. These studies could investigate the effects of corneal hypoxia at the cellular level and result in a new level of understanding of the processes involved.