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A Prospective Randomized Study on Low-Energy Extracorporeal Shock Wave Therapy for Erectile Dysfunction After Radical

Torben Brøchner Pedersen1,2, Caroline Secher1,2, Ali Moumneh1

  • 1Department of Urology, Odense University Hospital, Odense, Denmark.

The Journal of Urology
|April 27, 2025
PubMed
Summary

Low-energy shockwave therapy (LI-SWT) did not significantly improve erectile function in men post-prostatectomy compared to sham treatment. Erectile function outcomes remained similar between groups at 24 weeks.

Keywords:
erectile dysfunctionextracorporeal shock wave therapyprostatectomyprostatic neoplasms

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Area of Science:

  • Urology
  • Andrology
  • Regenerative Medicine

Background:

  • Radical prostatectomy often leads to erectile dysfunction.
  • Erectile function recovery is a significant concern for post-prostatectomy patients.
  • Low-energy extracorporeal shockwave therapy (LI-SWT) is being explored as a potential treatment.

Purpose of the Study:

  • To assess the efficacy of LI-SWT versus sham treatment for improving erectile function after radical prostatectomy.
  • To compare outcomes using the Erection Hardness Score (EHS) and International Index of Erectile Function (IIEF).

Main Methods:

  • 75 participants were randomized to LI-SWT or sham treatment.
  • Erectile function was evaluated at baseline and 4, 12, 24 weeks post-treatment.
  • Statistical analysis included zero-inflated negative binomial and nonparametric methods.

Main Results:

  • No statistically significant difference in IIEF scores between LI-SWT and sham groups (P=.469).
  • Median IIEF scores were 4 in both groups at 24 weeks.
  • No significant difference in EHS scores or the proportion of patients achieving sufficient erection hardness (EHS ≥3) at 24 weeks.

Conclusions:

  • LI-SWT did not demonstrate statistically significant improvement in erectile function compared to sham treatment in this patient cohort.
  • Further research may be needed to explore alternative or adjunctive therapies for post-prostatectomy erectile dysfunction.