Overcoming B-ALL Resistance to Targeted and Immune Therapies by Rational Combination Strategies
Miguel Quijada-Álamo1,2,3,4,5, Grace Freed1,2,3,4,5, Elvin Wagenblast1,2,3,4,5,6
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Blood Cancer Discovery
|April 27, 2025
Abstract:
Despite the remarkable efficacy of targeted therapies and immunotherapies in B-cell acute lymphoblastic leukemia (B-ALL), relapsed and refractory cases remain a major challenge. In this review, we discuss how integrating targeted agents with immunotherapy could help overcome resistance and improve long-term patient outcomes in B-ALL.
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