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A rare incidental finding during routine pathological evaluation of gallbladder specimen: a case report
Sarra Ben Rejeb1, Yasmine Chaabane1, Moez Sahnoun2
1Pathology Department, Security Forces Hospital, Marsa, Tunisia.
International Journal of Surgery Case Reports
|April 27, 2025
Summary
Gallbladder neuroendocrine tumors (NETs) are rare and often found incidentally. Routine pathology is key for diagnosing these asymptomatic tumors, which have a favorable prognosis with surgical management.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Neuroendocrine tumors (NETs) of the gallbladder are rare, presenting diagnostic and management challenges.
- Preoperative diagnosis is difficult due to nonspecific clinical and imaging findings, often mimicking common biliary conditions.
Observation:
- A 51-year-old man with hypertension presented with abdominal pain and Murphy's sign.
- Histopathology after cholecystectomy revealed a grade 1 NET invading the subserosa (pT2) at the cystic duct margin.
- Enlarged pericholedochal lymph nodes were noted, but staging showed no metastases.
Findings:
- A second surgery for cystic duct and regional lymph node resection showed no residual tumor.
- The patient received no adjuvant therapy and remains disease-free at 5 years post-surgery.
- Well-differentiated gallbladder NETs appear to have a favorable prognosis with surgical intervention.
Implications:
- This case underscores the critical role of routine pathological examination in detecting early-stage, asymptomatic gallbladder NETs.
- Early diagnosis and surgical management are crucial for favorable outcomes in gallbladder NETs.
- Further research is needed to establish clear adjuvant therapy guidelines for gallbladder NETs.
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