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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

41
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
41
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

26
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
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Autoimmune Disorders01:29

Autoimmune Disorders

363
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
363
Bulimia Nervosa01:30

Bulimia Nervosa

45
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Related Experiment Video

Updated: May 20, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
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Bidirectional causal effects between bipolar disorder and immune cell traits.

Jianbin Du1, Ancha Baranova2, Fuquan Zhang3

  • 1Department of Geriatric Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu 214151, China.

Journal of Affective Disorders
|April 27, 2025
PubMed
Summary

This study reveals a complex, bidirectional relationship between bipolar disorder (BD) and immune cell traits. Findings suggest immune cell variations impact BD risk and progression, offering new avenues for immunotherapeutic treatments.

Keywords:
Bipolar disorderImmune cellImmunologyMendelian randomization analysisPsychiatry

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Area of Science:

  • Immunology
  • Psychiatry
  • Genetics

Background:

  • Bipolar disorder (BD) pathogenesis is complex, hindering effective diagnosis and treatment.
  • The link between immune function and BD is observed but not fully understood.

Purpose of the Study:

  • To investigate the causal relationships between bipolar disorder (BD) and immune cell traits.
  • To explore bidirectional causal effects between BD and 731 immune cell traits using Mendelian randomization.

Main Methods:

  • Utilized a two-sample Mendelian randomization approach with publicly available GWAS data.
  • Analyzed 41,917 cases and 371,549 controls for BD and 731 immune cell traits.
  • Performed sensitivity analyses using MR-Egger intercept and Cochran's Q test.

Main Results:

  • No significant causal link found between BD and six basic white blood cell types.
  • Identified 38 immune cell traits with causal effects on BD; 26 increased risk (e.g., CD4+/CD28+ T cells), 12 showed protective effects.
  • BD causally affected 33 immune cell traits, with a stronger overall causal effect on immune cells than vice versa.

Conclusions:

  • Established a complex network of bidirectional causal relationships between BD and immune cell phenotypes.
  • Findings offer novel insights for BD diagnosis and treatment through an immunotherapeutic lens.