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Updated: May 10, 2025
Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration
Published on: March 7, 2019
Bioinspired hydrogel microspheres enhance nucleus pulposus regeneration through N-cadherin interaction with
Xin Tian1, Yan Miao2, Hao Liu3
1Department of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou 215000, Jiangsu, China; Orthopaedic Institute, Suzhou Medical College, Soochow University, Suzhou 215000, China; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg 41346, Sweden.
Abstract:
Intervertebral disc degeneration (IVDD) is a common cause of debilitating spinal conditions, necessitating regenerative therapies to restore tissue function. This study explores the potential of enhancing nucleus pulposus cell (NPC) viability and extracellular matrix (ECM) synthesis through surface modification of GelMA microspheres with His-Ala-Val (HAV) peptides. The HAV peptides, mimicking N-cadherin's adhesive properties, aim to promote cell-cell interactions akin to NPCs' native environment. In vitro studies demonstrated enhanced ECM secretion by NPCs cultured on HAV-functionalized GelMA microspheres, suggesting a potential for improved regenerative capacity. The microspheres promoted NP tissue regeneration when implanted in rat tail IVDs post-discectomy, indicating their therapeutic efficacy in vivo. This research provides insights into novel strategies for enhancing cell-material interactions in tissue engineering applications to mitigate IVDD.
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