Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Ā Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A survey on treatment satisfaction with leuprorelin acetate in girls with central precocious puberty.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric EndocrinologyĀ·2026
Same author

Antioxidant Therapy Reverses Sound Stress-Induced Opioid Resistance in a Mouse Model of Mechanical Allodynia.

Journal of pain researchĀ·2026
Same author

A Case of Successful Stent Retriever Angioplasty Using the Tigertriever for Acute M1 Segment Occlusion of the Middle Cerebral Artery due to Atherosclerotic Disease.

Journal of neuroendovascular therapyĀ·2026
Same author

Tree-Structured Orthonormal Decomposition of the Aitchison Simplex.

ArXivĀ·2026
Same author

A Nomogram Predicts the Need for Internal Iliac Vein Dissection During Renal Transplantation: A Multicenter Collaborative Study.

Transplantation proceedingsĀ·2026
Same author

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARĪ³2 at K382.

CellsĀ·2026

Related Experiment Video

Updated: Jul 13, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

72.0K

5-Aminolevulinic acid improves spatial recognition memory in mice.

Sora Komiya1, Yukako Takekawa1, Chinatsu Ohmori1

  • 1Laboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.

European Journal of Pharmacology
|April 27, 2025
PubMed
Summary

Supplementing with 5-aminolevulinic acid (5-ALA) improves memory and cognitive function by enhancing brain plasticity and neurotransmitter balance. This suggests 5-ALA may be a therapeutic strategy for cognitive dysfunction.

Keywords:
5-Aminolevulinic acidLearningLong-term potentiationOblivionRetrieval

More Related Videos

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

9.4K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.2K

Related Experiment Videos

Last Updated: Jul 13, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

72.0K
A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

9.4K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.2K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • 5-aminolevulinic acid (5-ALA) is crucial for heme biosynthesis and cellular respiration.
  • Recent studies suggest exogenous 5-ALA may alleviate cognitive impairments.
  • Understanding 5-ALA's role in cognition requires investigating its molecular mechanisms.

Purpose of the Study:

  • To elucidate the contributions of 5-ALA to cognition.
  • To investigate the underlying molecular mechanisms of 5-ALA's cognitive effects.
  • To examine 5-ALA's impact on novel object recognition, spatial memory, and long-term potentiation (LTP).

Main Methods:

  • Administration of 5-ALA via intracerebroventricular and oral routes in male ddY mice.
  • Assessment of novel object recognition (NOR) and Y-maze spontaneous alternation.
  • Electrophysiological recording of LTP in hippocampal slices and measurement of glutamate/GABA ratio.

Main Results:

  • Both administration routes of 5-ALA enhanced object recognition memory in NOR tests.
  • Oral 5-ALA administration improved spatial memory in the Y-maze test.
  • 5-ALA increased the glutamate/GABA ratio and enhanced LTP, mediated by CP-AMPARs.

Conclusions:

  • 5-ALA administration improves spatial recognition memory and cognitive function.
  • Enhanced LTP and altered glutamate/GABA ratio are key molecular mechanisms.
  • Exogenous 5-ALA supplementation shows potential for treating cognitive dysfunction.