The Role of Infrasound and Audible Acoustic Sound in Modulating Wound Healing: A Systematic Review

This systematic review evaluates the therapeutic effects of infrasound (1-20 Hz) and low-frequency audible sound (20 Hz-20 kHz) on wound healing, with a focus on cell migration, tissue regeneration, and bone repair. A comprehensive literature search across PubMed, Scopus, and Google Scholar was conducted to synthesise current data on these acoustic frequencies' impact on cellular functions. Key findings indicate that infrasound enhances bone growth and osteogenic differentiation of bone marrow stem cells, significantly accelerating fracture healing by increasing bone mineral density. Low-frequency sound at 100 Hz promotes fibroblast migration and alters cell morphology through actin restructuring, with effects varying by horizontal versus vertical vibrations. Additionally, frequencies of 10 and 20 kHz stimulate epidermal wound healing in mice by activating keratinocyte functions. These results highlight the potential of specific acoustic frequencies as non-invasive, cost-effective wound treatment options, particularly for bone regeneration and chronic wounds. Further research is recommended to refine acoustic parameters and validate clinical applications to establish therapeutic protocols.