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Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain
Natalie R Osborne1,2, Kevin M Hellman1,2, Emily M Burda1
1Department of Obstetrics & Gynecology, Endeavor Health, Evanston, IL, United States.
Pain
|April 27, 2025
Summary
Adolescent widespread pain is predicted by premenarchal somatic symptoms and hypersensitivity to visual stimuli. This hypersensitivity is a novel risk factor for developing widespread pain after puberty.
Area of Science:
- Pain research
- Adolescent health
- Neuroscience
Background:
- Widespread pain in adolescence is associated with poor mental health and somatic symptoms.
- Understanding predictors of widespread pain is crucial for early intervention.
Purpose of the Study:
- To identify premenarchal predictors of postmenarchal widespread pain in adolescents.
- To investigate the association between widespread pain and menstrual pain intensity.
Main Methods:
- Prospective study of 207 premenarchal adolescents.
- Utilized quantitative sensory testing (QST) and multimodal hypersensitivity (MMH) measures.
- Assessed somatic symptoms, psychosocial factors, and somatosensory function.
Main Results:
- 29% of participants developed new widespread pain postmenarche.
- Elevated somatic symptoms, stress, and hypersensitivity to visceral and visual stimuli predicted widespread pain.
- Premenarchal body map score, somatic symptoms, and visual hypersensitivity predicted postmenarchal widespread pain.
Conclusions:
- Increased sensitivity to multimodal stimuli is a novel risk factor for adolescent widespread pain.
- Early identification of somatic symptoms and hypersensitivity may aid in preventing widespread pain development.
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