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Published on: March 21, 2025
Clinicopathologic Profile and Pelvic Magnetic Resonance Imaging Pattern of Prostate Cancer in Southeast Nigeria
S K Anyimba1, E C Ajare2, O M Mbadiwe1
1Department of Surgery, College of Medicine, Urology Division, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.
Background:
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men. It is the commonest cancer in Nigerian men. Multiparametric magnetic resonance imaging (mpMRI) is essential in the evaluation of patients with PCa.
Aim:
To evaluate the clinicopathologic profile and pelvic MRI pattern of prostate cancer patients.
Methods:
This was a retrospective study performed between July 2020 and June 2024. The study population was derived from men with histologically diagnosed PCa who subsequently had mpMRI for cancer staging. From the medical records, age, prebiopsy PSA, Gleason score (GS) and other relevant information were obtained.
Results:
The records of 458 subjects were retrieved. A total number of 229 subjects had their prebiopsy PSA recorded while 158 subjects had their GS recorded. The mean age of the subjects was 66.38 ± 8.46 years, while the mean and median prebiopsy PSA were 49.37 ± 59.81 ng/ml and 33ng/ml, respectively. The mean GS of the subjects was 7.72 ± 1.29. The prostate capsule was the most commonly invaded structure (65.4%). The prevalence of bone metastasis was 22.8%, and the spine was the most commonly affected bone. Stage 3 and stage 4 disease were the most predominantly observed (58.4% and 32%, respectively). There was a statistically significant but weak correlation between tumor stage and GS.
Conclusion:
The subjects' clinicopathologic profile and pelvic MRI findings show that patients commonly present with advanced prostate cancer in our environment.
Insights
Nigerian men with prostate cancer (PCa) often present with advanced disease. Multiparametric MRI (mpMRI) aids in evaluating PCa clinicopathologic profiles and MRI patterns, revealing common findings in advanced stages.
Area of Science:
- Oncology
- Radiology
- Urology
Background:
- Prostate cancer (PCa) is a leading malignancy in men globally and the most common cancer in Nigerian men.
- Multiparametric magnetic resonance imaging (mpMRI) is a crucial tool for evaluating patients diagnosed with PCa.
Purpose of the Study:
- To investigate the clinicopathologic characteristics of prostate cancer patients.
- To analyze the pelvic MRI patterns associated with prostate cancer in the study population.
Main Methods:
- Retrospective study conducted from July 2020 to June 2024.
- Included men with histologically confirmed PCa who underwent pelvic mpMRI for staging.
- Extracted data included age, prebiopsy Prostate-Specific Antigen (PSA), Gleason Score (GS), and tumor stage.
Main Results:
- Analysis of 458 subjects revealed a mean age of 66.38 years.
- Mean prebiopsy PSA was 49.37 ng/ml (n=229), and mean GS was 7.72 (n=158).
- Advanced disease was prevalent: prostate capsule invasion (65.4%), bone metastasis (22.8%), and predominantly Stage 3 (58.4%) and Stage 4 (32%) disease.
Conclusions:
- Clinicopathologic and pelvic MRI findings indicate a tendency for advanced prostate cancer presentation in the studied population.
- Highlights the importance of mpMRI in characterizing advanced PCa and its patterns.
