Related Experiment Video
Updated: Aug 18, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Jaundice associated with cephalosporin therapy
Abstract:
Two cases of cephalosporin-induced hepatotoxicity with associated jaundice are presented. Both patients developed jaundice and liver enzyme abnormalities soon after injectable cephalosporin therapy was started. Other possible causes were ruled out, including TPN and allopurinol hepatoxicity, and additional medical illnesses associated with hepatoxicity. Both patients recovered fully from the episode of jaundice. Review of the literature suggests a possible hypersensitivity reaction similar to liver toxicity of the penicillin antibiotics.
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