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Related Experiment Videos

Verapamil-rifampin interaction.

R A Barbarash

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Rifampin significantly reduces verapamil levels, potentially causing supraventricular tachycardia (SVT) recurrence. Stopping rifampin and switching to ethambutol normalized verapamil levels and controlled SVT.

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    Area of Science:

    • Pharmacology
    • Cardiology
    • Infectious Disease

    Background:

    • Verapamil is a calcium channel blocker used to treat supraventricular tachycardia (SVT).
    • Rifampin is a key antibiotic for treating pulmonary tuberculosis.
    • Drug interactions can impact therapeutic efficacy and patient outcomes.

    Observation:

    • A patient with SVT on high-dose verapamil experienced recurrent symptoms.
    • Serum verapamil concentrations were found to be critically low during rifampin therapy.
    • Concurrently, the patient was being treated with rifampin for pulmonary tuberculosis.

    Findings:

    • Rifampin co-administration led to significantly reduced serum verapamil levels.
    • Discontinuation of rifampin and substitution with ethambutol increased verapamil levels nearly four-fold.

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  • The change in medication regimen resulted in effective control of the patient's SVT.

    • Implications:

    • Rifampin may induce hepatic microsomal enzymes, accelerating verapamil metabolism.
    • This interaction can lead to therapeutic failure in managing SVT.
    • Clinicians should consider this potential interaction when prescribing rifampin to patients on verapamil.