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Updated: May 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Visible-light-induced acridinium-catalyzed selective N-dealkylation of N-heterocycles
Shanshan Liu1, Yaoyao Zhang1, Xianying Zhou1
1Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, P. R. China. liushanshan@sust.edu.cn.
Abstract:
We have developed an efficient and general strategy for N-chlorosuccinimide (NCS)-promoted N-dealkylation of aza-heterocycles via acridinium-photocatalyzed electron transfer and hydrogen atom transfer. This approach effectively obviates the need for transition metal catalysis and features wide substrate scope as well as exclusive chemo-selectivity. Remarkably, the method allowed the deprotection of the privileged but stable N-alkyl group, thus filling a gap in the practical N-dealkylation of N-heteroaromatics.
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