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Updated: Jul 15, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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Ergodic Manipulation of Genome Chaos: Innovative Strategies against Malignant Progression

Sergey Shityakov1, Viacheslav Kravtsov1

  • 1Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, Lomonosova str. 9, 191002, Saint Petersburg, Russia.

Current Cancer Drug Targets
|April 28, 2025
PubMed

Keywords:
Genomic instabilityapoptosiscancer stem cellscancer therapeuticscell differentiation therapychromosomal instabilityepigenetic regulation in cancerergodicitygenome catastrophesmolecular targeted therapy.mutationtargeted therapy

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