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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Exercise Mimetics in Aging: Suggestions from a Systematic Review.

Emiliana Giacomello¹, Claudio Nicoletti², Marta Canato³

¹Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.

|April 28, 2025

Summary

Exercise mimetics, compounds mimicking exercise benefits, offer new health strategies for aging populations. Many natural compounds and dietary supplements act as exercise mimetics, linking nutrition and exercise for enhanced well-being.

Keywords:

aging exercise exercise mimetics health span lifespan metabolism myokines natural compounds nutrient sensing pathway

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Area of Science:

Gerontology and Nutritional Science
Molecular Biology and Exercise Physiology

Background:

Aging populations face increased comorbidities, impacting quality of life.
Diet and physical exercise are key health promotion strategies.
Challenges exist in applying exercise to older adults, necessitating alternative approaches.

Purpose of the Study:

To systematically review exercise mimetics and their relationship with nutrition.
To explore compounds and strategies that mimic the physiological effects of exercise.

Main Methods:

Systematic literature search of PubMed and Scopus databases.
Keyword used: "exercise mimetics".
Analysis and discussion of 97 selected research articles.

Main Results:

Multiple exercise-mimetic compounds and physical strategies identified.
These mimetics target metabolic pathways, oxidative stress, and myokine modulation.
A significant number of exercise mimetics are natural products and dietary supplements.

Conclusions:

Exercise mimetics offer promising health interventions for aging.
Natural products and supplements play a key role as exercise mimetics.
Nutrition is central to the development and application of exercise mimetics.