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Development of a Method for Visualizing and Quantifying Thrombus Formation in Extracorporeal Membrane Oxygenators.

Jenny S H Wang1, Amelia A Rodolf1, Caleb H Moon1

  • 1Department of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Ave, Portland, OR 97239 USA.

Cellular and Molecular Bioengineering
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Summary

A new method quantifies thrombus formation in extracorporeal membrane oxygenation (ECMO) devices. This technique analyzes oxygenator thrombosis patterns, aiding in developing new treatments for device-associated thrombosis.

Keywords:
Computed tomographyExtracorporeal membrane oxygenationMedical device-associated thrombosisThrombosis

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Area of Science:

  • Biomedical Engineering
  • Critical Care Medicine
  • Medical Device Technology

Background:

  • Extracorporeal membrane oxygenation (ECMO) is vital for critical care but carries high risks of device-associated thrombosis.
  • Understanding thrombus formation within ECMO devices is crucial for patient safety and treatment efficacy.

Purpose of the Study:

  • Develop a comprehensive method for collecting and analyzing thrombus formation in used ECMO membrane oxygenators.
  • Quantitatively assess the distribution and patterns of thrombosis within the membrane lung.

Main Methods:

  • Collected explanted membrane oxygenators from ECMO patients.
  • Utilized microcomputed tomography (microCT) for imaging and 3D reconstruction.
  • Applied image segmentation and density mapping to quantify thrombus volume and distribution.

Main Results:

  • Achieved 2D and 3D visualization and quantification of thrombus deposition in ECMO devices.
  • Detailed analysis of spatial distribution of platelets, red blood cells, and fibrin.
  • Identified structural patterns of oxygenator thrombosis.

Conclusions:

  • The developed method enables precise quantification of oxygenator thrombosis.
  • Facilitates evaluation of novel biomaterials and pharmacological interventions to mitigate ECMO-related thrombosis.