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Related Experiment Videos

Temocillin penetration of peripheral lymph.

T Bergan, W L Olszewski, A Engeset

    Drugs
    |January 1, 1985
    PubMed
    Summary

    Temocillin effectively penetrates peripheral lymph tissue in humans, reaching concentrations that indicate good distribution. This pharmacokinetic profile suggests favorable tissue penetration for this penicillin antibiotic.

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    Area of Science:

    • Pharmacokinetics
    • Antibiotic Research
    • Human Physiology

    Background:

    • Temocillin is a penicillin antibiotic with a broad spectrum of activity.
    • Understanding antibiotic distribution into tissues like lymph is crucial for optimizing treatment efficacy.
    • Previous studies on penicillin penetration into lymph are limited.

    Purpose of the Study:

    • To investigate the pharmacokinetic profile of temocillin in human peripheral lymph and serum.
    • To determine the extent and rate of temocillin penetration into interstitial lymph fluid.
    • To assess the influence of serum protein binding on temocillin's lymph penetration.

    Main Methods:

    • Intravenous administration of 1g temocillin to 5 healthy volunteers.
    • Serial sampling of peripheral lymph, serum, and urine over 12 hours post-administration.
    • Quantification of temocillin concentrations using validated analytical methods.
    • Pharmacokinetic analysis including peak concentrations, half-life, and area under the concentration-time curve (AUC).

    Main Results:

    • Temocillin achieved significant concentrations in peripheral lymph (14.3 mg/L at 1 hour, peak 30.6 mg/L).
    • Lymph concentrations were consistently lower than simultaneous serum concentrations (58.1 mg/L at 1 hour, peak 47.8 mg/L).
    • The ratio of total AUC in lymph to serum was 0.56, indicating substantial lymph penetration, which was better than expected for a highly protein-bound penicillin.

    Conclusions:

    • Temocillin demonstrates good penetration into human peripheral lymph following intravenous administration.
    • Serum protein binding may influence the rate of lymph penetration, but overall penetration is favorable.
    • The pharmacokinetic data supports the potential clinical utility of temocillin in infections involving lymphatic tissues.

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