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Summary
Temocillin, a new beta-lactam antibiotic, achieves high concentrations in bile after intravenous or intramuscular administration. This suggests its potential use in treating Gram-negative biliary infections.
Area of Science:
- Pharmacology
- Microbiology
- Gastroenterology
Background:
- Temocillin is a novel semisynthetic beta-lactam antibiotic effective against aerobic Gram-negative bacteria.
- Biliary excretion of antibiotics is crucial for treating Gram-negative biliary infections.
Purpose of the Study:
- To investigate the biliary excretion of temocillin.
- To determine if temocillin achieves therapeutic concentrations in bile.
Main Methods:
- 15 patients with normal liver and renal function undergoing cholecystectomy received 1g of temocillin intravenously or intramuscularly.
- Bile and serum concentrations of temocillin were measured 1-2 hours post-administration.
Main Results:
- Very high temocillin concentrations (up to 8x serum levels) were found in common bile duct and gallbladder bile.
- Concentrations were higher with intravenous administration and correlated with serum levels.
- No temocillin was detected in non-functioning gallbladders.
Conclusions:
- Temocillin readily achieves therapeutic concentrations in bile.
- Temocillin may be useful for prophylaxis and treatment of Gram-negative biliary infections.