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Study of Risk Factors Associated with Bad Outcome among Pediatric Patients with Tubercular Bacterial Meningitis

Sarika Gupta1, Akanksha D Srivastava2

  • 1Department of Paediatrics, King George Medical University, Lucknow, Uttar Pradesh, India.

Journal of Global Infectious Diseases
|April 28, 2025
PubMed

Insights

Older children with altered consciousness, hydrocephalus, low CSF-to-plasma glucose ratio, or no Bacille Calmette-Guerin (BCG) immunization face higher risks of poor outcomes in tubercular bacterial meningitis (TBM). Early treatment is crucial.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Tubercular bacterial meningitis (TBM) poses a significant threat to pediatric populations globally.
  • Identifying risk factors for poor outcomes is crucial for effective management and improved patient prognosis.

Purpose of the Study:

  • To evaluate the risk factors associated with adverse outcomes in children diagnosed with TBM.
  • To inform clinical practice and public health strategies for TBM management.

Main Methods:

  • A retrospective cohort study involving 514 pediatric TBM patients from 2019-2023.
  • Statistical analysis using SPSS version 16.0 to identify predictors of poor outcomes.

Main Results:

  • 19.1% of patients experienced poor outcomes.
  • Key risk factors identified include: age >5 years (OR=2.291), altered consciousness (OR=2.829), CSF-to-plasma glucose ratio <50% (OR=0.410), hydrocephalus (OR=2.857), and lack of BCG immunization (OR=3.638).

Conclusions:

  • Childhood TBM is a severe public health concern with identifiable risk factors for poor outcomes.
  • Timely initiation of antituberculosis therapy is essential, alongside targeted interventions for high-risk individuals.
Abstract

Keywords:
Bad outcomechildrenhydrocephalusmeningitisrisk factortuberculosis

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