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Controlling nutritional status score is a predictor of survival in hepatocellular carcinoma: A meta-analysis and
1Yi Chen, Department of Interventional Radiotherapy, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou University, Huzhou, Zhejiang Province 313000, P.R. China.
Objective:
The controlling nutritional status score (CONUT) has been utilized for prognostication of several cancers but its utility for hepatocellular carcinoma (HCC) is still unclear. We reviewed evidence on the ability of CONUT to predict overall survival (OS) and disease-free survival (DFS) in patients with HCC.
Methods:
Online repositories of PubMed, Embase, CENTRAL, and Web of Science were searched by two reviewers for English language studies and were available before 15th March 2024. Hazard ratio (HR) and 95% confidence intervals were calculated for both OS and DFS.
Results:
A total of fourteen studies were available. Meta-analysis showed that CONUT was a significant predictor for OS (HR: 1.64 95% CI: 1.30, 2.06) and DFS (HR: 1.32 95% CI: 1.17, 1.50) in HCC. The effect size failed to change in significance on sensitivity analysis. Subgroup analysis based on country and treatment of HCC did not change the results. Subgroup analysis and meta-regression showed that a higher CONUT cut-off led to a stronger association between CONUT and OS in HCC.
Conclusions:
CONUT can be an easy-to-use and rapid prognostic indicator for HCC. High CONUT scores are associated with worse OS and DFS.
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