Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative in vitro activity of temocillin.

M Gobernado, E Canton

    Drugs
    |January 1, 1985
    PubMed
    Summary

    Temocillin, a novel beta-lactam antibiotic, shows strong antibacterial activity against Gram-negative bacteria. This penicillin is a promising option for treating hospital infections caused by these organisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent <i>Candida</i> spp. to Triazoles and Amphotericin B and Aspergillus spp. to Caspofungin: Further Assessment of Modal Variability.

    Antimicrobial agents and chemotherapy·2021
    Same author

    Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in <i>Candida</i> and <i>Aspergillus</i> Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods.

    Antimicrobial agents and chemotherapy·2018
    Same author

    Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method.

    Antimicrobial agents and chemotherapy·2016
    Same author

    In vitro activity of anidulafungin in combination with amphotericin B or voriconazole against biofilms of five Candida species.

    The Journal of antimicrobial chemotherapy·2016
    Same author

    In Vitro Studies of Tigemonam: a Comparison of the Minimum Inhibitory and Minimum Bactericidal Concentrations (MIC vs MBC).

    Journal of chemotherapy (Florence, Italy)·2016
    Same author

    Erratum to: Species distribution and in vitro antifungal susceptibility profiles of yeast isolates from invasive infections during a Portuguese multicenter survey.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2015

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Beta-lactam antibiotics are crucial in treating bacterial infections.
    • Emerging resistance necessitates the development of new antimicrobial agents.
    • Gram-negative bacterial infections pose a significant threat in hospital settings.

    Purpose of the Study:

    • To evaluate the in vitro antibacterial activity of temocillin.
    • To compare temocillin's efficacy against Gram-negative clinical isolates with other antibiotics.
    • To assess temocillin's potential for treating Gram-negative hospital-acquired infections.

    Main Methods:

    • Testing the antibacterial activity of temocillin against 796 clinical isolates.
    • Conducting a comparative analysis with 8 other antibiotics.
    • Determining the minimum inhibitory concentrations (MICs) for susceptible strains.

    Main Results:

    • Temocillin demonstrated significant activity against Gram-negative bacteria, including Escherichia coli and the genera Proteus, Enterobacter, Serratia, Klebsiella, Citrobacter, Providencia, Salmonella, Shigella, and Haemophilus.
    • 98% of tested strains were inhibited by temocillin at concentrations ≤16 mg/L.
    • Temocillin exhibited favorable in vitro activity compared to some other tested antibiotics.

    Conclusions:

    • Temocillin possesses potent in vitro antibacterial activity against a wide range of Gram-negative pathogens.
    • Its efficacy suggests potential as a valuable therapeutic agent for Gram-negative bacterial infections.
    • Combined with favorable pharmacokinetic properties, temocillin is a promising penicillin for hospital infections.

    Related Experiment Videos