Clinical Efficacy of Continuous Renal Replacement Therapy in Patients with Pulmonary Tuberculosis Complicated with Sepsis: A Retrospective Observational Study
Related Experiment Video
Updated: May 10, 2025
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
Published on: October 25, 2024
Xin Chen1, Xiaoqing Lin1, Fang Cheng1
1Department of Infectious Disease, Wenzhou Central Hospital, Dingli Clinical College of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People's Republic of China.
Objective:
To explore the clinical efficacy of continuous renal replacement therapy (CRRT) in patients with pulmonary tuberculosis (TB) complicated with sepsis, particularly focusing on 28-day mortality (primary objective), and to assess the impact of CRRT on inflammatory response, renal function, haemodynamics and overall prognosis (secondary objectives).
Methods:
A total of 98 patients with pulmonary TB complicated by sepsis were included: 49 patients were enrolled in the control group and received routine treatment, whereas 49 patients were enrolled in the CRRT group and received CRRT based on the control group. Renal function indicators, inflammatory indicators, haemodynamic indicators and recovery status were analysed and compared.
Results:
After 72 hours of treatment, C-reactive protein (CRP), serum creatinine (SCR), blood urea nitrogen (BUN) and plasma lactic in the CRRT group decreased (P < 0.001), procalcitonin (PCT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were reduced (P < 0.01) and urine volume and mean arterial pressure (MAP) increased (P < 0.001). After 72 hours of treatment, CRP and PCT in the control group increased (P < 0.05), SCR, BUN and NT-proBNP increased (P < 0.001), plasma lactic was not significantly changed and MAP decreased (P < 0.05). The 28-day mortality in the CRRT group was lower than in the control group (28.6% vs 49%, P = 0.038), intensive care unit hospitalisation time was shorter than in the control group (11.27 ± 9.34 vs 15.43 ± 9.19 d, P = 0.028) and Acute Physiological Function and Chronic Health Status Scoring System II and Sequential Organ Failure Score scores were lower after treatment (P < 0.001). The difference was statistically significant.
Conclusion:
Continuous renal replacement therapy can significantly improve inflammatory response, enhance haemodynamics, promote renal function recovery and increase overall treatment efficacy in patients with pulmonary TB complicated with sepsis.
Related Concept Videos
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...