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Recurrent Glioblastoma Resection with Microvascular Free Flap Reconstruction and Associated GammaTile Implantation: A
Russel T Wagner1, Jacopo Berardinelli2, Amin B Kassam1
1Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States.
Journal of Neurological Surgery Reports
|April 28, 2025
Summary
This study presents a novel approach combining GammaTile radiation therapy with free flap reconstruction for recurrent glioblastoma (GBM) patients experiencing wound complications. The combined treatment showed no adverse effects on tissue viability, suggesting a safe and potentially effective strategy for complex GBM reconstruction.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Plastic and Reconstructive Surgery
Background:
- Glioblastoma multiforme (GBM) recurrence is common despite aggressive treatments.
- Scalp soft tissue integrity can be compromised by multiple surgeries and chemoradiation, necessitating complex reconstruction.
- Local radiation therapy is an emerging approach for GBM, offering potential advantages over traditional methods.
