Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Renally Excretable Gold Nanoparticle Oncology Platform Enabling Effective Photothermal Therapy and Chemotherapy Combination.

ACS nano medicine·2026
Same author

The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity.

Drug delivery·2026
Same author

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate?

OncoTargets and therapy·2025
Same author

Trehalose-stabilized micelle-in-microparticles of icariin targeting IL-4 pathway in chronic obstructive pulmonary disease.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Evaluation of Antioxidant and Anti-Inflammatory Effects of a Nanoformulation Derived from Annurca Apple Callus Extract in an In Vitro Model of Iron Overload-Induced Inflammation.

Antioxidants (Basel, Switzerland)·2025
Same author

DAHD-YOLO: A New High Robustness and Real-Time Method for Smoking Detection.

Sensors (Basel, Switzerland)·2025

Related Experiment Video

Updated: May 10, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

8.9K

Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy.

Chengwei Jiang1, Rongjun Bai1, Satyanarayana Somavarapu1

  • 1Department of Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K.

ACS Omega
|April 28, 2025
PubMed
Summary

This study developed inhalable micelles for codelivering curcumin and icariin to treat non-small cell lung cancer (NSCLC). The formulation showed enhanced anticancer activity and suitability for deep lung delivery.

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.2K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

8.8K

Related Experiment Videos

Last Updated: May 10, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

8.9K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.2K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

8.8K

Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Oncology

Background:

  • Non-small cell lung cancer (NSCLC) presents significant therapeutic challenges, including drug resistance and poor solubility of conventional agents.
  • Hydrophobic bioactive compounds like curcumin (CUR) and icariin (ICA) show anticancer potential but require effective delivery systems.

Purpose of the Study:

  • To develop and evaluate inhalable micelles for the co-delivery of curcumin and icariin for targeted NSCLC therapy.
  • To assess the physicochemical properties, in vitro cytotoxicity, and aerosolization performance of the developed nanomicelles.

Main Methods:

  • Optimization of micellar formulation using TPGS/DPPC (9:1 ratio) for co-delivery of CUR and ICA.
  • Characterization of nanomicelles for size, zeta potential, encapsulation efficiency, and stability.
  • In vitro cytotoxicity assays against A549 lung cancer cells and DPPH radical scavenging assays.
  • Aerosolization studies to evaluate fine particle fraction and emitted fraction for pulmonary delivery.

Main Results:

  • Optimized nanomicelles (∼18 nm) exhibited high encapsulation efficiency (∼90%) and stability for pulmonary administration.
  • CUR- and ICA-loaded micelles demonstrated enhanced in vitro cytotoxicity against A549 cells (IC50 = 3.0 μg/mL), surpassing doxorubicin.
  • Encapsulation preserved curcumin's antioxidant functionality, and aerosolization studies confirmed suitability for deep lung deposition.

Conclusions:

  • Inhalable CUR- and ICA-loaded micelles represent a promising strategy for targeted NSCLC treatment via pulmonary drug delivery.
  • The developed nanomicelles offer improved efficacy and delivery of hydrophobic anticancer agents.
  • Further preclinical studies are warranted to validate this novel therapeutic approach for NSCLC.