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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
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Bladder angiosarcoma: a systematic literature review and survival analysis
Amisha Silwal1, Sumie B R2, Shafi Rehman3
1Department of Medicine, Cagayan State University College of Medicine, Tuguegarao, Cagayan, Philippines.
Proceedings (Baylor University. Medical Center)
|April 28, 2025
Summary
Bladder angiosarcoma (BA) is an aggressive cancer. This review of 68 patients found metastasis and female gender are poor prognostic factors, while chemotherapy may improve survival.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Bladder angiosarcoma (BA) is a rare vascular malignancy.
- Sporadic cases are infrequently reported, necessitating comprehensive reviews.
Purpose of the Study:
- To systematically review clinicopathological features of bladder angiosarcoma.
- To analyze survival outcomes and identify prognostic factors.
Main Methods:
- Systematic review of 35 cases involving 68 patients.
- Analysis of clinicopathological data, immunohistochemistry, and survival outcomes.
- Multivariate Cox regression for prognostic factor identification.
Main Results:
- 51.4% de novo and 48.6% radiation-induced BA.
- Hematuria (76.4%) was the most common symptom; metastasis occurred in 71.6%.
- Female gender, metastasis, and chemotherapy were independent prognostic factors (p<0.01).
Conclusions:
- Bladder angiosarcoma is aggressive, irrespective of etiology.
- Early detection and prompt chemotherapy initiation may enhance patient survival.
- Further research into BA pathogenesis and treatment is warranted.
