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Related Experiment Video

Updated: May 10, 2025

An Orthotopic Resectional Mouse Model of Pancreatic Cancer
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Characteristics and outcomes of observed versus resected pancreatic neuroendocrine tumors.

Caroline Breit1, Bobby Dow1, Masen Ragsdale1

  • 1Division of Surgical Oncology, Baylor University Medical Center, Dallas, Texas, USA.

Proceedings (Baylor University. Medical Center)
|April 28, 2025
PubMed
Summary

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Observation may be safe for small, incidentally discovered pancreatic neuroendocrine tumors (pNETs). Management decisions for pNETs require individualized assessment, potentially including multidisciplinary tumor board input.

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms with variable clinical behavior.
  • Treatment strategies range from surgical resection to observation for select cases.
  • Understanding factors influencing treatment choice is crucial for optimal patient management.

Purpose of the Study:

  • To compare outcomes of initial resection versus observation for pancreatic neuroendocrine tumors (pNETs).
  • To identify tumor characteristics that guide the selection between resection and observation.
  • To evaluate the safety and efficacy of observation for small, incidentally discovered pNETs.

Main Methods:

  • Retrospective review of patients diagnosed with pNETs at a tertiary referral center (2018-2023).
Keywords:
Neuroendocrine tumorobservationpNETpancreaspancreatic neuroendocrine tumor

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  • Collection of data on patient demographics, tumor characteristics, treatment course, and outcomes.
  • Comparison of cohorts undergoing initial resection, observation, or delayed resection.

    • Main Results:

    • 33% underwent initial resection, 37% observation, 30% delayed resection.
    • Younger patients with fewer comorbidities and symptomatic tumors favored initial resection.
    • Tumors >2 cm were associated with higher postoperative complication rates.
    • In incidentally discovered tumors ≤2 cm, observation (66%) showed no progression over 17 months; delayed resection (33%) had no complications.

    Conclusions:

    • Observation can be a safe option for select patients with small, incidentally discovered pNETs.
    • Surgical resection remains the primary treatment for pNETs.
    • Individualized treatment decisions, supported by multidisciplinary tumor boards, are essential for pNET management.