Expression of CD44 and Its Correlation With Clinicopathological Factors in Oral and Oropharyngeal Carcinoma: A Retrospective Immunohistochemical Study
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View abstract on PubMed
Summary
This summary is machine-generated.CD44, a cancer stem cell marker, shows decreasing expression in oral squamous cell carcinoma as differentiation lessens. This finding highlights CD44
Area Of Science
- Oncology
- Cancer Stem Cell Biology
- Immunohistochemistry
Background
- CD44 is a key cancer stem cell marker (CSC) implicated in oral and oropharyngeal cancer progression.
- It plays vital roles in cell adhesion, angiogenesis, invasion, and migration.
Purpose Of The Study
- To assess CD44 expression in oral and oropharyngeal squamous cell carcinoma (OOSCC) using immunohistochemistry.
- To compare CD44 expression across different histological grades of OOSCC.
- To correlate CD44 expression with patient prognosis.
Main Methods
- Retrieved 70 OOSCC paraffin-embedded blocks (well, moderately, and poorly differentiated).
- Evaluated CD44 immunostaining intensity via immunohistochemistry.
- Analyzed the statistical significance of CD44 expression differences across grades using the chi-square test (p < 0.05).
Main Results
- All 70 OOSCC cases exhibited CD44 immunopositivity with varying intensities.
- Strong CD44 staining was prevalent in well-differentiated OOSCC (29/31 cases).
- CD44 expression intensity significantly decreased with reduced tumor differentiation (p < 0.05).
Conclusions
- CD44 expression diminishes as oral and oropharyngeal squamous cell carcinoma becomes less differentiated.
- The study establishes a significant inverse relationship between CD44 expression and histological grade in OOSCC.
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