Related Experiment Video
Updated: May 10, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
A Comprehensive Review of Electrolyte Imbalances and Their Applied Aspects in Dermatology
KavyaDeepu R M1, Mohnish Sekar2
1Dermatology, Chettinad Hospital and Research Institute, Chennai, IND.
Abstract:
Electrolytes play a pivotal role in the maintenance of neutrality in the minerals of the cells - also, the generation and conduction of action potentials in neurons and muscles. Key electrolytes include sodium, potassium, chloride, magnesium, calcium, and phosphate. Electrolyte imbalances can result in elevated or diminished levels. Abnormal electrolyte levels, whether raised or decreased, interfere with normal physiological activities and may result in life-threatening consequences. Electrolyte imbalances are common in critical care units, although they are less frequent in dermatological conditions. Dermatologists should, however, be knowledgeable about the skin disorders and medications that are related to or may increase the risk of electrolyte imbalance to ensure that appropriate treatments are implemented immediately to avoid negative results. The objective of this review is to narrate the dermatological features of disorders involving abnormalities of sodium, potassium, calcium, phosphorus, and magnesium.
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Roles of Electrolytes: Sodium and Potassium
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

