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Central Nervous System Involvement in Splenic Marginal Zone Lymphoma
Kabeer Ali1, Jennifer Miatech2, Falguni Patel1
1Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus
|April 28, 2025
Summary
Marginal zone B-cell lymphoma (MZL) rarely affects the central nervous system (CNS). This case highlights the diagnostic and therapeutic challenges of secondary CNS involvement in splenic MZL presenting as status epilepticus.
Area of Science:
- Hematology
- Neurology
- Oncology
Background:
- Marginal zone B-cell lymphoma (MZL) is a heterogeneous indolent non-Hodgkin lymphoma (NHL).
- MZL typically involves nodal, extranodal sites, or the spleen.
- Central nervous system (CNS) involvement in MZL is uncommon, presenting as primary dural lymphoma or secondary infiltration.

