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An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction.

Ane Olazagoitia-Garmendia1,2, Henar Rojas-Márquez2,3, Tim Trobisch4

  • 1Department of Biochemistry and Molecular Biology, University of Basque Country UPV/EHU, 48940 Leioa, Spain.

Molecular Therapy. Nucleic Acids
|April 28, 2025
PubMed
Summary
This summary is machine-generated.

Long non-coding RNA LOC339803 plays a role in neuronal cells, impacting mitochondrial integrity and potentially contributing to multiple sclerosis (MS) pathogenesis. This suggests LOC339803 as a marker for mitochondrial dysfunction and a therapeutic target in neurodegeneration.

Keywords:
MT: non-coding RNAsRNA modificationSNPbraincell-specificitylncRNAmetabolismmitochondriamultiple sclerosisneuroinflammation

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Non-coding SNPs linked to immune diseases often reside in regulatory elements like long non-coding RNAs (lncRNAs).
  • lncRNAs are implicated in various cellular functions, making them potential therapeutic targets.
  • The lncRNA LOC339803, located in an autoimmunity-associated region, has a known proinflammatory role in intestinal disorders.

Purpose of the Study:

  • To investigate the function of lncRNA LOC339803 specifically within neuronal cells.
  • To explore the role of LOC339803 in the pathogenesis of multiple sclerosis (MS).

Main Methods:

  • Analysis of human brain samples.
  • Application of diverse in vitro techniques to study lncRNA function.
  • Assessment of hexokinase 2 (HK2) levels and mitochondrial integrity.

Main Results:

  • Demonstrated a distinct function of LOC339803 in neuronal cells.
  • Showed that LOC339803 maintains hexokinase 2 (HK2) levels, preserving mitochondrial integrity.
  • Partially elucidated the involvement of LOC339803 in the pathogenesis of multiple sclerosis (MS).

Conclusions:

  • Highlights the necessity of cell-type-specific investigations for regulatory lncRNAs.
  • Identifies LOC339803 as a potential biomarker for mitochondrial dysfunction in neurodegenerative diseases.
  • Proposes LOC339803 as a candidate for therapeutic intervention in neurodegeneration.