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Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer

Yanlin Cao1,2, Yuxing He3, Lingshan Liao1

  • 1Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.

Frontiers in Oncology
|April 28, 2025
PubMed

Insights

Circular RNAs (circRNAs) are key gene regulators in colorectal cancer. Understanding their role in immunotherapy can lead to new biomarkers and treatments for better patient outcomes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are crucial regulators of gene expression at multiple levels.
  • Their tissue-specific and developmental regulation implicates them in physiological processes and diseases, especially cancer.
  • Dysregulated circRNAs significantly impact colorectal cancer progression.

Purpose of the Study:

  • To investigate the role of circRNAs in colorectal cancer (CRC).
  • To explore circRNAs as potential biomarkers and therapeutic targets in CRC immunotherapy.
  • To highlight advancements in circRNA-based precision medicine for CRC.

Main Methods:

  • Analysis of circRNA expression patterns in colorectal cancer.
  • Investigating molecular mechanisms of circRNA influence on disease progression.
  • Reviewing current and future circRNA-based therapeutic strategies and delivery systems.

Main Results:

  • Circular RNAs show significantly dysregulated expression in colorectal cancer.
  • CircRNAs influence colorectal cancer progression through diverse molecular mechanisms.
  • CircRNAs play a complex role in modulating colorectal cancer immunotherapy outcomes.

Conclusions:

  • Circular RNAs are pivotal in colorectal cancer, affecting gene expression and disease progression.
  • CircRNAs hold promise as biomarkers and therapeutic targets for colorectal cancer immunotherapy.
  • Advancements in circRNA therapeutics can enhance precision medicine for early diagnosis and improved prognosis in colorectal cancer.
Keywords:
circular RNAcolorectal cancerdiagnosisimmunotherapyprecision medicine

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