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The Role of Cavin3 in the Development of Malignant Tumors

Lei Qian1,2, Ziqian Zhang3, Hongning Cai2

  • 1Hubei University of Medicine, Shiyan, Hubei Province, 442000, People's Republic of China.

Cancer Management and Research
|April 28, 2025
PubMed

Insights

Cavin3 acts as a tumor suppressor in various cancers by regulating caveolae formation. It shows anti-tumor effects in breast and lung cancers via the PI3K/AKT pathway and DNA repair, and in gastric cancer by stabilizing p53.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cavin3 (PRKCDBP/SRBC) is a key regulator of caveolae formation and function.
  • It acts as a tumor suppressor in many malignant tumors, often regulated by promoter methylation.

Purpose of the Study:

  • To systematically review Cavin3's role in breast, lung, gastric, colorectal, and gynecological cancers.
  • To focus on Cavin3's impact on tumor prognosis and its regulatory mechanisms.

Main Methods:

  • Systematic literature review of studies on Cavin3 in various cancer types.
  • Analysis of Cavin3's involvement in signaling pathways and cellular processes.

Main Results:

  • Cavin3 inhibits the PI3K/AKT pathway and aids DNA repair in breast and lung cancers.
  • In gastric cancer, Cavin3 stabilizes p53, inducing cell cycle arrest and apoptosis.
  • Cavin3's precise role and mechanisms in other cancers require further investigation.

Conclusions:

  • Cavin3 exhibits significant anti-tumor activity across multiple cancer types.
  • Understanding Cavin3's broader mechanisms could lead to novel precision oncology strategies.
  • Further research is essential to fully elucidate Cavin3's therapeutic potential.
Keywords:
Cavin3biomarkersignaling pathwaytumor suppressor

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